Multi-tenant project yields much-needed research space in Lexington

Callahan Construction Managers (Callahan),a full-service construction management company headquartered in Bridgewater, Mass., announced today that it has completed a multi-phase renovation project for Revolution Labs in Lexington. The project features a 180,000 square foot core and shell research building that is occupied by anchor tenants Orum Therapeutics and Alchemab Therapeutics.

The facility was designed from the ground up to support both cutting-edge research and the lifestyle needs of today’s life sciences pioneers. Orum Therapeutics is a private, clinical-stage biotechnology company that is pioneering the development degrader-antibody conjugates (DCAs) for cancer treatment, while Alchemab Therapeutics is developing solutions that utilize the immune system to create novel antibody therapies for challenging diseases.

With a proven track record for overseeing complex, technical, and multi-phase projects, Callahan’s familiarity with working in occupied spaces as well as the unique challenges of the life sciences environment proved impactful while working for Revolution Labs. The team was chosen to first oversee the core and shell of the facility, and then later retained to manage the fit-out of the interior office and lab spaces. The occupied nature of the building during the second phase posed challenges that included lining the pipes of the structure’s sanitary system while the building was in use, requiring restricted water use and proactive planning with laboratory tenants.

In addition, the ongoing supply chain concerns made procurement of advanced laboratory components challenging, including specialty HVAC and electrical equipment. Callahan utilized the pre-construction phase to build a schedule that met critical deadlines while also taking into account what equipment needed to be ordered first to ensure occupancy goals were not impacted by unpredictable delivery dates. Fortunately, strong relationships with suppliers and subcontractors ensured Revolution Labs maintained its preferred timeline.

With the health and safety of occupants a priority, Revolution Labs is on track to achieve WELL Certification. For Callahan, knowing it has helped build a facility that promotes both cutting-edge research and the health of its occupants makes the successful completion a source of pride for all involved.


“We are thrilled to see this new research facility come to life to support the groundbreaking efforts of the researchers that work here,” said Steve Callahan, Jr., vice president – business development, Callahan. “This project showcases the benefit of robust pre-construction planning, along with having a team that understands the specialized nature of lab construction. We wish Revolution Labs well as they utilize this space to its maximum potential.”

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About Callahan Construction Managers
Callahan Construction Managers is a full-service construction management company based in Bridgewater, Mass., with a regional office in White Plains, NY.  Callahan has served the New England and Northeast regions for over 70 years. As one of the region’s largest open shop construction firms, Callahan provides a wide range of preconstruction and construction management services to local, regional, and national clients. Callahan’s markets include multi-family residential, senior housing, affordable housing, hospitality, life sciences, corporate office, educational, retail and tenant fit up. Callahan was voted a 2022 “Top Place to Work” by the Boston Globe and 2021 “Best Place to Work” by the Boston Business Journal. Visit www.callahan-inc.com for more information.


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The life sciences market is rapidly changing – that much we know. While no one can predict the future, it is possible to build a cutting-edge laboratory and research facility that will adapt to the changing needs of scientists and researchers. That’s what is unfolding at 440 Bedford, a completely new approach to lab space in the coveted Lexington submarket.

440 Bedford Street is a new 6-story, 335,000 GSF Class AA speculative life science lab and office building being built by Callahan Construction. When finished, the building will include incubator lab space, graduator lab space, lab-ready spaces, a café, fitness center and other amenities. The building will also feature a retail and restaurant space on the first level and several outdoor amenities, along with a 6-level parking garage with parking for 575 vehicles. Put simply, this isn’t just a place to come work; it’s a destination for collaboration and an extension of one’s lifestyle.

Callahan’s pre-construction expertise was on full display during the early phases of the project, as the construction team discovered soil deficiencies that had the potential to cause substantial delays to the project schedule and significant costs to the budget if not resolved as early as possible. The preconstruction team as well as Callahan’s Site Division were able to find solutions to the problem that kept the project on schedule, saved money for the client, and strengthened trust between all parties on the project.

440 Bedford will feature numerous high-end touches, including modern interiors designed to inspire, flooded with natural light and plenty of amenities to keep scientists balanced. And with its location in the sought-after Lexington and Hartwell Avenue submarket, 440 Bedford offers ease of access to both the building and nature, not to mention proximity to other innovative companies and industries along with mass transit.

“Callahan is excited to once again leverage its experience with complex projects including laboratories and research facilities, along with our robust portfolio of pre-construction services, to build 440 Bedford,” said Steve Callahan Jr., Vice President – Business Development, Callahan Construction. “The team behind this project in Lexington knows how important it is to bring this cutting-edge research space to market, and we look forward to seeing it filled with the people and projects changing our world for the better.”

For more information about Callahan’s pre-construction services, please visit https://callahan-inc.com/our-services/enhanced-preconstruction-services/.

Waltham, MA – Callahan Construction Managers announced that Lincoln Property Company’s 300 Third Avenue project in Waltham has been awarded LEED Gold Certification from the U.S. Green Building Council (USGBC). Callahan provided construction management services at this 4-story, 139,000sf Class A facility, located in the Rt. 128 Tech Corridor.

Representatives of Callahan say that, in concert with DiMella Shaffer Architects, the firm was selected to oversee the construction of 300 Third Avenue thanks to its deep experience in laboratory construction as well as green building, and that when the project wrapped up in early 2022, it brought to market four stories of laboratory and office space with highly efficient mechanical, chemical storage and utility areas to service the most demanding laboratory operations.

From a sustainability standpoint, 300 Third Avenue offers a variety of green-focused features designed to support efficient building operations and sustainable lifestyle choices. Attaining Gold certification denotes that a building has excelled in its sustainable design and operation, securing over 60% of the available LEED points. Features like electric car charging stations, bike storage and showers, and shuttle access to MBTA Waltham are all designed to help building occupants make decisions that help support reduced carbon emissions and road-going traffic.

In addition to achieving LEED Gold status, 300 Third Avenue is also WiredScore Gold Certified. This certification recognizes and promotes digitally connected buildings across the globe, and proves that a building has the digital infrastructure in place to support companies now and in the future.

Representatives of Callahan say the firm makes every effort to provide clients with sustainable and efficient materials and equipment options, adding that the company currently has 30 Passive House certified licensed professionals on staff, and is proud to have leveraged this in-house expertise to achieve LEED Gold at the Waltham site.

“The need for sustainable building and flexible laboratory space has never been more important in today’s market, with tenants looking for options that will both serve their existing and future space requirements, along with providing healthy environments for employees,” said Steve Callahan Jr., vice president of business development, Callahan. “300 Third Avenue is a perfect example of how teams can work together to create highly sought after space while reducing the building’s impact on the environment, and we are happy to see it receive this impressive certification from the USGBC.”

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